Work

Sarcoidosis With Isolated Osseous Manifestations Mimicking Metastatic Malignancy

Year: 2025

Type: article

Abstract: Sarcoidosis is an inflammatory disease of unknown etiology that commonly involves multiple organ systems, with the lungs and lymph nodes most frequently affected. Osseous involvement, although recognized, is considered uncommon and often overlooked due to its nonspecific clinical and radiographic features. Patients may be asymptomatic or present with pain, swelling, and functional limitations of the affected limb. Imaging can reveal findings such as bone lesions that mimic malignancy, including lytic or sclerotic changes. Diagnosis relies on histopathological confirmation of non-caseating granulomas. Treatment is directed at symptom relief and preservation of limb function. Here, we present a rare case of isolated osseous sarcoidosis in a 38-year-old African American female that mimicked metastatic malignancy on imaging and responded dramatically to steroids.

Source: Cureus

DOI: 10.7759/cureus.97536

Authors: Ahmed Ismail, Ahmed Saleh, Yanis Boumber

Institutions: Eastern Virginia Medical School, University of Alabama at Birmingham, O'Neal Comprehensive Cancer Center, Old Dominion University, Kazan Federal University

Language: English

Topic: Sarcoidosis and Beryllium Toxicity Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416553413