Work

Co-expression of a retrotransposon and re-targeted restriction factor impairs yeast growth

Year: 2025

Type: article

Abstract: minimizes replication of Ty1 family retrotransposons using an inhibitory protein identical to the C-terminal domain of the transposon's capsid protein. We previously elucidated the molecular basis of restriction and subfamily specific targeting and engineered a re-targeted restriction factor. Here, we report that co-expression of the Ty1' retrotransposon and a variant of its restriction factor mutated to re-target a related transposon subfamily impairs yeast growth.

Source: PubMed

DOI: 10.17912/micropub.biology.001905

Author: Sean L Beckwith

Institution: Hope College

Language: English

Topic: Chromosomal and Genetic Variations

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W4416554665

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