Work

Profiling truncated variants of TCTN1 unveils the essential role of its integrity for ciliogenesis

Year: 2025

Type: article

Abstract: ; DUF1619 alone aggravates ciliary defects. In particular, deletion of either terminus decreases TZ localization and, for the C-terminus, destabilizes the protein during ciliary disassembly. Thus, our findings demonstrate that the full-length TCTN1, rather than DUF1619 alone, is indispensable for ciliary integrity.

Source: iScience

DOI: 10.1016/j.isci.2025.114190

Authors: Huimin Yu, Lin Jiang, Chuang Xu, Ya Li, Suhui Wang, Zhao Ma, Yunyao Qian, Yiqiong Wu, Chenyu Miao, Zhouzhou Dong, Liang Wang

Institution: Jiangsu Normal University

Language: English

Topic: Genetic and Kidney Cyst Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Jiangsu Normal University, Priority Academic Program Development of Jiangsu Higher Education Institutions, Xuzhou Science and Technology Bureau

Award: G6378730635

OpenAlex ID: W4416566342

FWCI:

Cites: 55

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