Work

Synthesis of a Stimulus-Sensitive Copolymer with Response to Temperature and pH in Silicone Catheters

Year: 2025

Type: article

Abstract: Co gamma-ray source (Gammabeam 651 PT). The temperature- and pH-responsive monomers, N-vinylcaprolactam (NVCL) and N-vinylimidazole (NVIM), respectively, were grafted onto silicone catheters. The effects of irradiation dose and monomer concentration on grafting efficiency were studied. A direct relationship was found between grafting efficiency and both irradiation dose and monomer concentration. As these parameters increased, the grafting percentage also increased. The biomaterial was characterized by using Fourier-Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM), swelling, and a water contact angle measurement. The swelling behavior was also investigated by varying temperature and pH. The Lower Critical Solution Temperature (LCST) was observed around 34 °C, and pH sensitivity was detected between pH 8 and 8.5. Mechanical tests were performed to conduct a systematic analysis relating to the grafting percentage and the ratio between grafted polymers and Young's modulus. Finally, the loading and release capacity of norfloxacin in the modified catheters was evaluated.

Source: Polymers

DOI: 10.3390/polym17233107

Authors: Yanet González Alonso, Emilio Bucio

Institution: Universidad Nacional Autónoma de México

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funders: Universidad Nacional Autónoma de México, Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México