Terretonin P and additional new compounds from mesophilic Aspergillus terreus MSM18
Year: 2025
Type: article
Abstract: We present terretonin P (1), a novel oxygenated tetracyclic meroterpenoid derived from the mesophilic Aspergillus terreus MSM18, alongside a tetra-hydrofurano-acrylic acid derivative (2a), its 5’-epimer (3a), the respective 5’-methylethers (2b, 3b), the new microbial 3-prenyl-4-hydroxy-benzaldehyde (4a), and our previously reported terretonins M-O (5–7). Structurally, the new compounds (1–4a) have been clarified through comprehensive analyses of NMR (1D, 2D) spectroscopy and HR-ESIM spectrometry. The relative configuration of compounds 1–3a,b was established through NOESY experiment. The separation and taxonomical characterisation of A. terreus MSM18, along with the antimicrobic properties of the newly identified compounds (1–4a) as well as the corresponding fungal extract were investigated as well.
Source: Natural Product Research
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4416572701