Year: 2025
Type: article
Abstract: Ferroptosis, an iron-dependent and lipid peroxidation-driven mode of regulated cell death, holds significant pathological significance. Its dysregulation manifests in dual facets: inhibition promotes tumorigenesis, whereas overactivation aggravates neurological disorders and organ injury. This paper systematically reviews the core molecular mechanisms of ferroptosis and provides a comprehensive summary of recent advances in its modulators: inducers classified by targets (GPX4 axis, iron metabolism, lipid metabolism, and GPX4-independent antioxidant pathways) and inhibitors classified by source (synthetic and natural). It places a particular focus on summarizing and analyzing the optimization strategies, mechanisms of action, existing limitations, and future directions for novel ferroptosis modulators, to offer valuable insights for future drug development targeting ferroptosis.
Source: Pharmaceuticals
DOI: 10.3390/ph18121785
Authors: Junwei Chen, Zhonglang Gou, Guoxin Yang, Lingli Zhou, An Na Kim, Wenchao Shi, You Zhou
Institution: Southwest University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Award: G7114594832
OpenAlex ID: W4416574734