Work

LDHA associated with telomerase-related genes promotes tumorigenesis and progression of lung adenocarcinoma

Year: 2025

Type: article

Abstract: Lung adenocarcinoma (LUAD) is a lung cancer subtype with poor prognosis and high heterogeneity, posing significant challenges in clinical management. Telomerase-related genes (TRGs), crucial for chromosomal stability and tumor progression, have an unclear link to LUAD prognosis. In this study, we developed a 12-TRG-based risk model using genomic and clinical data from the TCGA and GEO databases, demonstrating high precision in predicting outcomes for patients with LUAD. We comprehensively analyzed the model's correlation with clinical features, the tumor microenvironment (TME), and drug sensitivity. Notably, in vitro experiments confirmed that LDHA knockdown reduces LUAD cell invasion, migration, and proliferation. Our findings provide new insights into the molecular mechanisms of LUAD and highlight potential therapeutic targets, thereby advancing the understanding and treatment of this aggressive cancer.

Source: Scientific Reports

DOI: 10.1038/s41598-025-25626-9

Authors: Deng Pan, Bocheng Zou, Yujun Wang, Lijuan Yu

Institutions: First Affiliated Hospital of Nanchang University, Xiangya Hospital Central South University

Language: English

Topic: Lung Cancer Research Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690