Interplay between expression of PD-L1 on thyrocytes and intrathyroidal lymphocytes and FOXP3 as a marker of regulatory T lymphocytes in Hashimoto thyroiditis
Year: 2025
Type: article
Study design: Observational Study
Abstract: This study provides insight into the local immune environment of Hashimoto’s thyroiditis by analyzing the lymphocytic infiltrate in thyroid tissue directly. Key novel findings are the increased prevalence of FOXP3 + lymphocytes without a corresponding increase in CD25 + cells, suggesting a population of chronically activated regulatory T cells. It also identifies a distinct PD-L1 expression pattern in follicular cells (both membrane and cytoplasm), suggesting a protective feedback mechanism against autoimmune attack.
Institution: Universidade Estadual de Campinas (UNICAMP)
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4416589402