Work

FOXK2 gene expression in cancer: Potential regulatory mechanisms and clinical implications

Year: 2025

Type: article

Abstract: FOXK2 is a transcription factor known to regulate a wide range of biological processes that are critically involved in determining cell fate. Increasing evidence shows aberrant FOXK2 expression in some tumors, with crucial biological and clinical impacts. It is important to note that the molecular mechanisms contributing to FOXK2 gene deregulation are poorly understood for most cancers. In this review, we systematically describe the FOXK2 gene expression profile across distinct tumor types and discuss its potential utility as a prognostic and diagnostic molecular marker. Notably, we explore emerging mechanisms accounting for FOXK2 deregulation, focusing on genetic and transcriptional modifications, such as gene methylation, mutation and copy number variations.

Source: Genes & Diseases

DOI: 10.1016/j.gendis.2025.101951

Authors: Renata Ivo Vasconcelos, Luciana da Torre Carneiro, Raquel Ciuvalschi Maia, Thaís Hancio, Gabriela Nestal de Moraes

Institutions: Universidade Federal do Rio de Janeiro, Instituto Nacional de Câncer - INCA, Brazilian Center for Research in Energy and Materials, Brazilian Biosciences National Laboratory

Language: English

Topic: FOXO transcription factor regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500