Work

Tumor-derived exosomes as predictors of chemotherapy resistance in gastric cancer

Year: 2025

Type: article

Abstract: Chemotherapy resistance is a major obstacle in gastric cancer, limiting the efficacy of systemic therapy and contributing to poor survival. Tumor-derived exosomes are key mediators of chemoresistance, carrying microRNAs, long noncoding RNAs, and proteins that modulate apoptosis, drug efflux, and tumor-microenvironment interactions. Evidence from high-incidence countries, such as China and Japan, associates specific exosomal signatures with poor treatment response, and translational studies in Europe and North America are exploring their prognostic and predictive utility. Despite technical advances, clinical translation is hampered by inconsistent protocols, small cohorts, and limited regulatory frameworks. This letter reviews the biological and clinical evidence for exosome-mediated chemoresistance in gastric cancer and advocates for standardized methodologies, global validation studies, and integration into precision oncology pathways.

Source: Annals of Medicine and Surgery

DOI: 10.1097/ms9.0000000000004415

Authors: Muhammad Khizar, Hasibullah Aminpoor, Muhammad Zaib, Qaima Ali, Hasiba Karimi

Institutions: Georgian American University, Kabul University of Medical Sciences Abu Ali Ibn Sina, Bezmiâlem Vakıf Üniversitesi

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,850