Year: 2025
Type: article
Abstract: Adipose tissue is an organ with a high metabolic rate, functioning as a storage site for potential energy derived from food. It is a heterogeneous tissue composed of various cell types that respond differently to stimuli. Polyunsaturated fatty acids are lipids characterized by the presence of multiple double bonds in their molecular structure. These fatty acids are particularly vulnerable to oxidation by Reactive Oxygen Species, a process known as lipoperoxidation. While the oxidized lipids can serve important physiological roles within adipose tissue, they can also enter the bloodstream, where they associate with lipoproteins, leading to cellular damage and increased systemic oxidative stress. In cases of obesity, adipose tissue displays an exaggerated inflammatory and immune response that can affect multiple body systems, contributing to the onset of chronic degenerative diseases. Therefore, adipose tissue is a complex organ in which metabolic, endocrine, and immune response processes are intricately regulated and coordinated. This paper explains the role of alterations in redox balance, lipogenic, and inflammatory functions in adipose tissue as important risk factors for the development of chronic degenerative diseases, including those affecting the central nervous system. For this study, we searched multiple databases, including PubMed, Scopus, Google Scholar, the Cochrane Library, and Medscape, from 2015 to the present.
Source: Physiologia
Institution: Universidad Nacional Autónoma de México
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,207
OpenAlex ID: W4416592866