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A Cursory Gaze at Solitary Radiopharmaceutical Chelators Incorporating Macrocyclic and Acyclic Moieties

Year: 2025

Type: article

Abstract: Radiopharmaceutical development usually requires chelators to route radiometals to specific cancer targets. However, there is no universal chelator. To reduce off-target side effects, new chelators are needed as the radiometal toolset grows. DOTA is the most often used chelator for radiometals in radiopharmaceutical development, however DOTA's extreme conditions make it unsuitable for labeling heat sensitive biological vectors. The ideal chelator should be thermodynamically and kinetically stable, allowing labeling under mild conditions (~37 °C). In recent years, new hybrid chelators with enhanced characteristics have emerged, warranting further investigation for medical applications. This paper aims to discuss some of these promising chelators.

Source: Pharmaceutics

DOI: 10.3390/pharmaceutics17121508

Authors: Stephen Ahenkorah, Danni Ramdhani

Institutions: University of Iowa, University of Iowa Hospitals and Clinics, University of Iowa Health Care, Padjadjaran University

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $3,499

OpenAlex ID: W4416602182

FWCI: 1.061

Cites: 28

Cited by: 2

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