Comparative efficacy of r-hFSH Alfa + r-LH versus r-hFSH delta + hMG in poor ovarian responders
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Poor ovarian response (POR) remains a major limitation in assisted reproductive medicine. Direct comparisons between r-hFSH alfa + r-LH and r-hFSH delta + hMG in this population are scarce. Methods: This retrospective study included 437 POR patients treated between 2018 and 2022. Controlled ovarian stimulation involved either r-hFSH alfa + r-LH (Group A) or r-hFSH delta + hMG (Group B). After exclusions, 148 patients per group who reached embryo transfer were analyzed. Primary outcomes were total oocytes, metaphase II (MII) oocytes and embryos. Secondary outcomes included β-hCG positivity, clinical pregnancy and pharmacoeconomic evaluation. Results: Group A showed significantly higher numbers of oocytes (p=0.01), MII oocytes (p=0.02) and embryos (p=0.03). No significant differences in biochemical or clinical pregnancy were observed (OR 1.12; 95% CI: 0.79-1.59). The r-hFSH alfa + r-LH protocol required lower total gonadotropin doses and resulted in an average saving of €690 per additional MII oocyte. Discussion: The r-hFSH alfa + r-LH regimen improved ovarian response and cost-efficiency without affecting pregnancy outcomes. Prospective randomized trials are needed to confirm these results.
Source: Frontiers in Endocrinology
Institutions: University of Bari Aldo Moro, Stockholm IVF, Fondazione per le Scienze Religiose Giovanni XXIII, IVF Namba Clinic, Clinique Ovo, Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo, University of Palermo, University of Naples Federico II, Ospedale Madonna Delle Grazie
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4416603942