Selected parameters of epidermal barrier in juveniles with type 1 diabetes correspond with the severity of diabetes – an observational study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Our study aimed to evaluate the epidermal barrier function in children with type 1 diabetes. To the author's knowledge, no studies have been conducted on epidermal barrier parameters, including TEWL and measurement of epidermal hydration, in children and adolescents with type 1 diabetes. Methods: One hundred sixty children and adolescents aged 6-18, 125 patients with type 1 diabetes, and 35 healthy volunteers participated in the study: a detailed clinical evaluation, transepidermal water loss (TEWL) measurement, and epidermal hydration (corneometry) were carried out. Results: Poor metabolic control in type 1 diabetes, higher HbA1c(%), and more frequent hyperglycemia impact TEWL and epidermis hydration. Also, the level of BF(%) correlated positively with TEWL. Conclusions: Extended supplementary tests - the assessment of TEWL and corneometry - could be included in the periodic examinations of children and adolescents with type 1 diabetes mellitus. Clinicians should always pay attention to dry skin in children with diabetes, and noninvasive examination (TEWL measurement and corneometry) may allow us to isolate a group at risk of neuropathy or the development of the diabetic foot. Further tests enabling detailed assessment of the usefulness of TEWL measurements and corneometry are needed.
Source: Frontiers in Endocrinology
Institution: Poznan University of Medical Sciences
Language: English
Topic: Skin Diseases and Diabetes
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4416605894