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Refractory Penile Condyloma Acuminatum in an Elderly Man Receiving Vedolizumab and Azathioprine

Year: 2025

Type: article

Abstract: We report a case of an 83-year-old man who developed treatment-resistant penile condyloma acuminatum while receiving vedolizumab and azathioprine for ulcerative colitis. The patient had not engaged in sexual intercourse for more than five years. Laboratory findings revealed mild immunosuppression with decreased B-cell lymphocytes and low immunoglobulin A levels. The combined use of vedolizumab and azathioprine may have impaired genital mucosal immunity, leading to reactivation of latent human papillomavirus (HPV) infection. To our knowledge, condyloma acuminatum developing during vedolizumab therapy has rarely been reported, and this case suggests a potential association between vedolizumab and HPV reactivation.

Source: Cureus

DOI: 10.7759/cureus.97712

Authors: Sohei Iwagami, Haruka Miyai, Masaya Nishihata

Institutions: Wakayama Medical University, Kishiwada Tokushukai Hospital, Wakayama Medical University Hospital

Language: English

Topic: Genital Health and Disease

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416607041