Work

Chemoenzymatic Synthesis of Alkenes from Alcohols or Amines by One‐Pot Laccase‐Mediated Oxidations and Wittig Reaction in Water

Year: 2025

Type: article

Abstract: A general, chemoenzymatic one‐pot procedure for the transformation of alcohols or amines to the corresponding alkene products in aqueous media has been reported. The procedure is based on the laccase‐TEMPO‐mediated oxidations of substrates and subsequent Wittig reaction. In this way, a one‐pot sequence of two consecutive reactions has been developed, which has a number of advantages such as (a) no need of purification of the intermediate products, (b) application of water as green solvent and an enzyme‐laccase as natural catalyst, (c) application of molecular oxygen as final green oxidant, and (d) formation of water as a byproduct of the oxidation step.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70233

Authors: Ignacy Janicki, Piotr Kiełbasiński

Institutions: Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk, Polish Academy of Sciences

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Responsible consumption and production

Open Access status: bronze

Funder: Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk