Work

ACTC1 promotes tumor progression by upregulating BMP4 expression in prostate cancer

Year: 2025

Type: article

Abstract: Prostate cancer (PRAD) is a major malignancy affecting men worldwide. In this study, integrative analysis of public datasets and immunohistochemistry revealed that ACTC1 is upregulated in PRAD. Functional assays showed that ACTC1 overexpression promoted cell proliferation and migration, while its knockdown suppressed malignant behaviors. Consistently, xenograft experiments confirmed that ACTC1 enhanced tumor growth in vivo. Transcriptomic and pathway analyses indicated that ACTC1 regulates immune and inflammatory signaling, with BMP4 identified as a key downstream effector. Moreover, BMP4 overexpression rescued the inhibitory effects of ACTC1 knockdown on proliferation and migration, indicating that ACTC1 drives tumor progression through the BMP4 pathway. Together, our results identify ACTC1 as an oncogenic regulator of prostate cancer progression and suggest the ACTC1–BMP4 axis as a potential therapeutic target.

Source: BMC Cancer

DOI: 10.1186/s12885-025-15336-w

Authors: Ke Zhang, Ke Wu, Chunchun Zhao, Fei Wang, Chao Liu

Institutions: Suzhou Municipal Hospital, Nanjing Medical University

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,390