Work

Palladium‐Catalyzed Photoinduced Regioselective C8 Arylation of 1‐(Pyridin‐2‐yl)quinolin‐4(1 H )‐Ones with Aryl Diazonium Salts

Year: 2025

Type: article

Abstract: A visible‐light‐mediated regioselective C8 arylation of quinolinones has been developed by merging transition‐metal catalysis with photoredox catalysis. This approach offers broad substrate scope and mild reaction conditions, affording the desired products in up to 85% yield. Furthermore, to investigate the reaction mechanism, several control experiments were performed, including fluorescence quenching studies, quantum yield measurements, light‐on/off experiments, kinetic isotope effect (KIE) analysis, and H/D labeling experiments. This strategy exhibits excellent scalability and also enables subsequent C2 alkenylation.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500961

Authors: Shivaji V. Surve, Rajesh T. Bhawale, Biswajit Biswas, Umesh A. Kshirsagar

Institution: Indian Institute of Technology Indore

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Council of Scientific and Industrial Research, India, Indian Institute of Technology Indore

Award: G6851221199