Altered intra- and inter-network functional connectivity in pituitary adenomas with chiasmal compression
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Pituitary adenomas (PA) frequently compress the optic chiasm, leading to visual field defects (VFDs) and potentially affecting the function of brain networks. This cross-sectional study aimed to investigate alterations in brain networks in PA patients with chiasmal compression using resting-state functional magnetic resonance imaging (rs-fMRI). Methods: In this study, 35 PA patients with chiasmal compression and 33 healthy controls (HCs) were enrolled and underwent rs-fMRI scanning. Network-Based Statistic (NBS) and large-scale network analyses were performed. Additionally, correlations were analyzed between altered functional connectivity (FC) and suprasellar extension distance, duration of VFDs, as well as mean deviation (MD), reflecting the degree of VFDs. Results: Combining NBS and large-scale network analyses, we found that PA patients with chiasmal compression mainly showed significantly decreased intra- and inter-network connectivity, including the visual network (VN), dorsal attention network (DAN), ventral attention network (VAN), default mode network (DMN), frontoparietal network (FPN), somatosensory-motor network (SMN), and subcortical network (SCN). Moreover, the decreased mean FC values within VN and between VN-VAN were negatively correlated with suprasellar extension distance, and the decreased mean FC within VN was positively correlated with MD. Conclusions: This study highlights the widespread dysfunction of brain networks in PA patients with chiasmal compression. These findings offer new insights into the brain dysfunction in PA patients with chiasmal compression and could also aid in the evaluation of therapeutic efficacy for the disease.
Authors: Jing Tang, Wencheng Shen, Pingyi Zhu, Yuchen Liu, Pinfa Zou, Jurong Luo, Yuting Wang
Institutions: University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Third People's Hospital of Chengdu, Southwest Jiaotong University, Chongqing Medical University, Fudan University, Zhongshan Hospital, Wenzhou Medical University, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4416613574
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