Work

Phosphorescent iridium complexes activated by endogenous zinc as a mitochondrial DNA nuclease for stimulation of the cGAS-STING pathway

Year: 2025

Type: article

Abstract: The first case of a phosphorescent Ir( iii ) complex with dual functions in dysregulation of zinc homeostasis and generation of nuclease in situ .

Source: Chemical Science

DOI: 10.1039/d5sc07181j

Authors: Zhi-Yuan Li, Long-Bo Yu, Qing-Hua Shen, Liang Hao, Peng Wang, Xiao-Xiao Chen, Yu-Yi Ling, Cai-Ping Tan

Institutions: Sun Yat-sen University, Guangdong Medical College

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: diamond

Funders: National Natural Science Foundation of China, Sun Yat-sen University, Fundamental Research Funds for the Central Universities, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G6624290900, G7437354780, G8262754150

OpenAlex ID: W4416615691

FWCI: 1.117

Cites: 80

Cited by: 3

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