Work

Molecular insights into the role of selenoenzymes in the toxicity of methylmercury

Year: 2025

Type: article

Abstract: This combined experimental and computational approach provides a comprehensive mechanistic understanding of how selenoproteins modulate methylmercury toxicity through its preferential reactivity towards SeCys,leading to S–Hg–S(e) bridge formation.

Source: Inorganic Chemistry Frontiers

DOI: 10.1039/d5qi01958c

Authors: Mikel Bernabeu de Maria, Tshering Zangmo, Andrzej Gawor, Luigi Messori, Ewa Bulska, Joanna Szpunar, Ryszard Lobinski, Karinne Miqueu, Luisa Ronga

Institutions: Centre National de la Recherche Scientifique, Université de Pau et des Pays de l'Adour, Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux, University of Warsaw, University of Florence, Warsaw University of Technology

Language: English

Topic: Organoselenium and organotellurium chemistry

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: green

Funder: Agence Nationale de la Recherche

Award: Deepening into the molecular mechanisms of mercury neurotoxicity to rationalize new detoxification approaches

OpenAlex ID: W4416615701

FWCI: 2.678

Cites: 31

Cited by: 2

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