Figure S1 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Year: 2025
Type: other
Abstract: A. Bright field images of CCH1 and CCH2 cells B. CCH1 and CCH2 cells cells stained with antibody towards CD99 (green) and DAPI (blue) C. Western blots on CCH1 and CCH2 cell lysates probed with the indicated antibodies, confirming differences in EphA2 phosphorylation between CCH1 and CCH2. D. Immunofluorescence imaging of IGF1R-stained CCH1 and CCH2 cells starved, treated with IGF1 or treated with linsitinib for 2 hours. Individual channels are shown below the merged images. Nuclear IGF1R in CCH1 cells does not change localization with either treatment. IGF1 treatment induces slight internalization of IGF1R in CCH2 cells and this is inhibited by linsitinib.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4416627499