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Figure S5 from MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors

Year: 2025

Type: other

Abstract: Supplemental Fig.S5. Validation of select gene expression changes with TYK2 inhibitor treatment that were identified by qPCR array. JH-2-002 cells were incubated with 40 µMWU-12 or control for 48 hours, and gene expression was analyzed by qPCR for select(A)up-regulated or(B)down-regulated genes.

DOI: 10.1158/1078-0432.30706982

Authors: Dana C. Borcherding, Neha V. Amin, Kevin He, Xiaochun Zhang, Yang Lyu, Carina Dehner, Himanshi Bhatia, Angad Gothra, Layla Daud, Peter Ruminski, Christine A. Pratilas, Kai Pollard, Taylor Sundby, Brigitte C. Widemann, Angela C. Hirbe

Language: English

Topic: Neurofibromatosis and Schwannoma Cases

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4416628900

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