Work

Non-linear association between hepatic steatosis index and 3-month outcomes in patients with acute ischemic stroke

Year: 2025

Type: article

Abstract: OBJECTIVES: There is currently a limited understanding regarding the effect of hepatic steatosis index (HSI) on stroke prognosis. Therefore, we aimed to investigate the effect of HSI on 3-month unfavorable outcomes in adults with acute ischemic stroke (AIS). METHODS: Between January 2010 and December 2016, a prospective cohort study was conducted involving 1906 AIS patients receiving treatment at a hospital in South Korea. The effect of HSI on 3-month unfavorable outcomes was evaluated using a binary logistic regression model. Smoothed curve fitting and a generalized additive model were also employed to investigate the nonlinear correlation between HSI and unfavorable outcomes. RESULTS: Multivariate analysis revealed a significant inverse relationship between HSI and the likelihood of 3-month unfavorable outcomes (OR = 0.97, 95% CI 0.94-1.00, P = 0.028). Particularly, individuals with HSI values of 30-36 had a significantly reduced risk of unfavorable outcomes (OR = 0.59, 95% CI 0.44-0.79, P < 0.001) compared with those with HSI < 30, while this association was not statistically significant when HSI > 36. A nonlinear association was identified, with an inflection point at an HSI of 31.78. For HSI values ≤ 31.78, a significant negative correlation with 3-month unfavorable outcomes was observed (OR = 0.92, 95% CI 0.87-0.96, P = 0.001). However, for HSI values exceeding 31.78, the association between HSI and unfavorable outcomes did not reach statistical significance (OR = 1.01, 95% CI 0.97-1.06, P = 0.595). CONCLUSIONS: This study demonstrates a statistically significant inverse association between the HSI and 3-month unfavorable outcomes in patients with AIS, observed only when HSI values are below 31.78.

Source: European journal of medical research

DOI: 10.1186/s40001-025-03456-9

Authors: Changchun Cao, Mingxing Lou, Jie Jia

Institutions: Fudan University, First Affiliated Hospital of Fujian Medical University, Huashan Hospital

Language: English

Topic: Acute Ischemic Stroke Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190