Supplementary Figure S3 from Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts
Year: 2025
Type: supplementary-materials
Abstract: Overall survival of MDSRS+ with SRSF2 and TP53MH genotype stratified by RS burden. Cases (colored Kaplan-Meier curves) were compared to historical controls (gray curve) with similar clinical and molecular features and no RS (i.e. RS<5%) from two large studies evaluating clinical characteristics of SRSF2 and TP53MH -mutated MDS, respectively (ref. 2,3). SF3B1 mutated MDSRS+ were not considered for this analysis because of the small number of cases with RS between 5 and 15% (2 out of 82 SF3B1-mutated ones) and consolidated evidences in the literature showing no effect of RS burden on SF3B1-mutated MDS outcome (ref. 4,5); sample size also limited further analysis in the MDSRS+ NOS category.
Authors: Gabriele Todisco, Maria Creignou, Elsa Bernard, Ann-Charlotte Björklund, Pedro Luis Moura, Bianca Tesi, Teresa Mortera-Blanco, Birgitta Sander, Monika Jansson, Gunilla Walldin, Indira Barbosa, Susanne E. Reinsbach, Isabel Juliana Hofman, Christer Nilsson, Tetsuichi Yoshizato, Marios Dimitriou, David Chang, Svannildur Olafsdottir, Sigita Venckute Larsson, Magnus Tobiasson, Luca Malcovati, Petter Woll, Sten Eirik W. Jacobsen, Elli Papaemmanuil, Eva Hellström-Lindberg
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4416630345