Ubiquitous predictive processing in the spectral domain of sensory cortex
Year: 2025
Type: preprint
Abstract: The appearance at the anatomical level of a canonical laminar microcircuit suggests that each six-layer column of granular cortex may mediate a canonical computation. Hypotheses for such computations include predictive coding, predictive routing, efficient coding, and others. However, single-neuron recordings capture only the individual elements of the hypothesized laminar microcircuit, while local field potentials (LFPs) from a laminar probe offer insight into the broader population activity. Through the Allen Institute’s OpenScope Brain Observatory, data in mice performing a visual oddball task during multi-area laminar recording was used to test predictive processing hypotheses in the spectral domain. Histological labeling of the cortical laminae enabled a fine-grained examination of their roles in the task, and frequency bands capturing both feedforward and feedback effects were analyzed. ɣ-band local-field potential (LFP) oscillations conveyed feedforward prediction errors in lower sensory areas of cortex; ⍺/β-band oscillations weakened in unpredictable conditions compared to predictable ones; and θ-band oscillations additionally signalled slower, longer-scale temporal prediction errors. In combination with the previous findings, predictive routing explains these experiments where neither ubiquitous predictive coding nor feedforward adaptation can.
Source: eLife
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W4416632846