Long-term outcomes of persistent tachypnoea of infancy/neuroendocrine cell hyperplasia of infancy: study of the CRC chILD-EU

Year: 2025

Type: conference-paper

Abstract: Background: Long-term data on the clinical course of persistent tachypnea of infancy (PTI)/neuroendocrine cell hyperplasia of infancy (NEHI) remain limited. Aim: To evaluate long-term outcomes of PTI/NEHI patients. Methods: Among chILD-EU participating countries, clinical data of PTI/NEHI patients from diagnosis to age 13 were analyzed, including spirometry and chest CT results when available. The impact of systemic steroid (SS) treatment on symptoms at ages 2 and 4 was also assessed. Results: 185 patients (65% male, median diagnosis at 8 mo.) were included. Symptoms, chest CT, and spirometry abnormalities showed resolution over time (Table). Prevalence of tachypnea, retractions, hypoxemia, and crackles at ages 2 and 4 did not differ between SS-treated and untreated children. Conclusion: Most symptoms of PTI/NEHI resolve by age 4, although hypoxemia and crackles may persist into adolescence. Additional test abnormalities tend to normalize over time. SS treatment does not appear to affect symptom resolution. erj;66/suppl_69/OA5423/TB1 T1 TB1 Visit Baseline 18mo 2y 4y 6y 10y 13y Symptoms - n Tachypnoea - n (%) Retractions - n (%) Crackles - n (%) Hypoxemia - n (%) Failure to thrive - n (%) 185 180(97) 174(94) 157(85) 141(76) 83(45) 185 125(68) 101(55) 107(58) 113(61) 57(31) 153 62(41) 50(33) 72(47) 64(42) 33(22) 85 12(14) 8(9) 35(41) 25(29) 8(9) 52 7(13) 3(6) 19(37) 15(29) 4(8) 15 2(13) 0 5(33) 4(27) 4(27) 8 0 0 2(25) 1(13) 0 Follow-up chest CT - n Similar - n (%) Partial resolution - n (%) Complete resolution - n (%) Progression - n (%) 11 4(36) 7(64) 0 0 12 3(25) 6(50) 1(8) 2(17) 8 0 4(50) 4(50) 0 10 2(20) 4(40) 4(40) 0 4 0 3(75) 1(25) 0 1 1(100) 0 0 0 Spirometry - n Normal - n (%) ↓FVC - n (%) ↓FVC/FEV1 - n (%) 23 15(65) 8(35) 0 39 27(69) 10(26) 2(5) 15 14(93) 1(7) 0 8 8(100) 0 0

DOI: 10.1183/13993003.congress-2025.oa5423

Institutions: Medical University of Warsaw, LMU Klinikum, Ludwig-Maximilians-Universität München, University Children's Hospital Zurich, Medizinische Hochschule Hannover, Universitat de València, Copenhagen University Hospital, Rigshospitalet, Alder Hey Children's Hospital, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, University of Bern, University of Duisburg-Essen, Aristotle University of Thessaloniki, Innsbruck Medical University, Universität Innsbruck, Universitair Ziekenhuis Leuven, Centre for Inflammation Research, University of Edinburgh, National and Kapodistrian University of Athens, Necmettin Erbakan University, Ankara University, Universitätsmedizin Göttingen, University of Göttingen, University Hospital of Bern, Justus-Liebig-Universität Gießen, Bambino Gesù Children's Hospital, University Children's Hospital Tübingen, University of Tübingen, Semmelweis University, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, University Medical Center Groningen, University of Groningen, St. Josef-Hospital, Ruhr University Bochum, Charles University, University Hospital in Motol, Hospital Universitari i Politècnic La Fe, Sorbonne Université, Hôpital Armand-Trousseau, Assistance Publique – Hôpitaux de Paris

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4416635809