Minimal clinically important difference for the 1-minute sit-to-stand after pulmonary rehabilitation in exacerbations of COPD
Year: 2025
Type: conference-paper
Abstract: The established minimal clinically important difference (MCID) of functional recovery after pulmonary rehabilitation (PR) in stable patients may not apply in exacerbations of COPD (ECOPD). We estimated the MCID for the 1-minute sit to stand test (1STS) after PR in ECOPD. Patients with an outpatient-managed ECOPD who completed a 3-weeks home-based PR programme were included. The 1STS and COPD assessment test (CAT) were assessed pre- and post-PR. The global rate of change (GRC) set at 2, and the MCID established for the CAT, set at 2 for ECOPD and 3 for 3-weeks PR, were used as anchor. Mean change and linear regression were used as anchor-based methods; 0.5*standard deviation, standard error of measurement (SEM), 1.96*SEM and minimal detectable change were used as distribution-based methods. The MCID was pooled by weighting 2/3 to anchor- and 1/3 to distribution-based methods. 39 outpatients with ECOPD (90% male, 71±9yrs; FEV1 49±19%pred) were included. Moderate, significant correlations were found between the GRC and changes in the 1STS (rs=0.37, p=0.02), and changes in the CAT and 1STS (rs=-0.45, p=0.004). The pooled MCID for the 1STS was 3 repetitions (Fig. 1). An increase of 3 repetitions in the 1STS indicates clinically relevant improvements in functionality for outpatients with ECOPD undergoing PR. This MCID may now aid health professionals interpreting the results of PR in ECOPD. erj;66/suppl_69/PA673/F1 F1 F1
Authors: Ana Filipa Machado, Ana Oliveira, Cíntia Dias, António Pedro Gonçalves, Paula Simão, Chris Burtin, Alda Marques
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4416636689
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