Work

Bridging Radiology and Pathology: ATRX Loss and T2-FLAIR Mismatch as Early Diagnostic and Prognostic Markers in Diffuse Gliomas

Year: 2025

Type: article

Abstract: ATRX mutation and the T2-FLAIR mismatch sign have emerged as complementary molecular and imaging markers in diffuse gliomas. ATRX loss defines IDH-mutant astrocytoma at the molecular level, while the mismatch sign provides a non-invasive radiological clue with high specificity but limited sensitivity. Used together, they improve diagnostic precision, refine prognostic assessment, and guide individualized treatment planning.

Source: Journal of the Pakistan Medical Association

DOI: 10.47391/jpma.25-106

Authors: Quratulain Tariq, Eisha Abid Ali, Rahamah Arshad, Ahmad Sohail, Irfan Yousaf, Muhammad Shahzad Shamim

Institutions: Shaukat Khanum Memorial Cancer Hospital and Research Center, Aga Khan University, Aga Khan University Hospital

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650