Noncoding RNA molecules mediating skeletal muscle mitochondrial function and their potential applications in exercise molecular physiology: a systematic review
Year: 2025
Type: review
Study design: Systematic Review
Abstract: This systematic review investigates the role of noncoding RNAs (ncRNAs), including miRNAs, long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and transfer RNAs, in regulating mitochondrial biogenesis, dynamics, oxidative phosphorylation, and mitophagy in skeletal muscle and the potential applications of these ncRNAs in exercise molecular physiology. We conducted a comprehensive search in PubMed, Scopus, and Web of Science databases, identifying 45 relevant studies out of 2,378 records. The main findings indicate that miRNAs such as miR-128, miR-133a, miR-696, and miR-499 are critical regulators of mitochondrial function. Moreover, lncRNAs (lncEDCH1 and lncRNA-H19) and circRNA (circ-PTPN4) significantly influence mitochondrial biogenesis and function. Exercise interventions were shown to modulate the expression of these ncRNAs, particularly miR-133a and miR-696, leading to enhanced mitochondrial biogenesis and function. The review highlights the potential of these ncRNAs as biomarkers and therapeutic targets for improving mitochondrial function and treating metabolic and mitochondrial disorders. Further research is needed to explore the muscle-specific and exercise-modality-specific effects of ncRNAs to develop personalized interventions. Understanding the complex regulatory mechanisms of ncRNAs in mitochondrial adaptations can pave the way for innovative therapeutic strategies in exercise molecular physiology and metabolic health.
Institutions: Universidad Autónoma de Baja California, Universidad de Granada, Instituto de Salud Carlos III, Institut de Recerca Biomèdica Catalunya Sud, Universidad Internacional de La Rioja, Universitat Rovira i Virgili, Autonomous University of Chihuahua, Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4416659856