Work

In vivo inhibition of miR-125b-5p modulates monocyte trafficking through the CCR7 receptor and reduces atherosclerosis

Year: 2025

Type: article

Abstract: Our study investigates the role of inflammation and monocyte trafficking in atherosclerosis (ATH). We show that miR-125b-5p increases plaque inflammation and downregulates CCR7. Targeting miR-125b-5p with a specific antagomir restores CCR7 expression, enhances macrophage migration, and reduces both the inflammation and plaque size. The miR-125b-5p/CCR7 axis in ATH progression was further validated in a cohort of patients, suggesting that modulating this pathway may offer a novel therapeutic strategy.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00242.2025

Authors: Adrián Mallén, Noemí Rotllan, Raquel Griñán, Cristian Varela, Elena Bertolino, Valentina Paloschi, Lars Maegdefessel, Joan Carles Escolà-Gil, Josep Maria Aran, Fabrizio Sbraga, Arnau Blasco-Lucas, Joan Torras, Estanis Navarro, Miguel Hueso

Institutions: Institut d'Investigació Biomédica de Bellvitge, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Institut de Recerca Sant Pau, Universitat Autònoma de Barcelona, Technical University of Munich, Bellvitge University Hospital

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III, Agencia Estatal de Investigación

Awards: G1175115578, ESTUDIO DEL miR125B EN LA NEFROPATÍA DIABÉTICA: CONTRIBUCIONES DE LOS ÓRGANOS-ON-A-CHIP A LA MEDICINA PERSONALIZADA: PROYECTO iRoC, G8094693438, Mecanismos post-transcripcionales reguladores de la respuesta inflamatoria en aterosclerosis y Enfermedad Renal Crónica: Tráfico de macrófagos, polarización, formación de células espumosa

OpenAlex ID: W4416659927

FWCI: 0.305

Cites: 25

Cited by: 1

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