Work

Mn Oxide Nanowire/ZIF-8 Composites with Multiple Enzyme-like Activities for Enantioselective Glutamate Sensing

Year: 2025

Type: article

Abstract: A composite material of Mn oxide nanowires and ZIF-8 (MnxOy NWs@ZIF-8-RD) with controllable sizes and morphologies (rhombic dodecahedron-shape) was successfully synthesized under mild reaction conditions. The systematic investigation into the effects of synthesis conditions of the material on their microstructure and crystalline morphology was conducted. The material function as “tandem enzymes”, exhibiting multiple enzyme-like activities, such as peroxidase (POD)- and glutamate-oxidase (Glu OXD)-like activities. Kinetic studies reveal that the MnxOy NWs@ZIF-8-RD has excellent enzyme-like catalytic activity, with high substrate affinity and a maximum reaction rate of (H2O2: 840.52 × 10−8 M·S−1). MnxOy NWs@ZIF-8-RD shows remarkable enantioselectivity for Glu enantiomers based on its POD- and Glu OXD-like activities. By integrating theoretical and experimental approaches, the recognition mechanism was preliminarily elucidated. In short, this study offered valuable insights for developing sophisticated functional materials and provided methodological references for Glu enantiomer recognition and quantitative detection.

Source: Biosensors

DOI: 10.3390/bios15120771

Authors: Guo-Ying Chen, Mao-Ling Luo, Jing-Jing Dai, Feng-Qing Yang

Institution: Chongqing University

Language: English

Topic: Advanced Nanomaterials in Catalysis

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,654

Funders: National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities