Work

The choline chloride/hydroquinone carboxylic acid-based DES as a novel catalyst for the green synthesis of dihydrochromeno[4,3-d]pyrimidinediones

Year: 2025

Type: article

Abstract: A novel deep eutectic solvent (ChCl/HCA-DES) was prepared by combining two moles of choline chloride (ChCl) with one mole of hydroquinone carboxylic acid (HCA), based on the results from the eutectic point phase diagram, and characterized by FT-IR, ¹H NMR, TGA/DTA, densitometry, viscometry, and refractive index analyses. Then, it was subsequently employed as an efficient, environmentally friendly and sustainable catalytic system for the synthesis of dihydrochromeno [4,3-d]pyrimidinediones via the three-component condensation reaction of 4-hydroxycoumarin, aromatic aldehydes, and urea at 60 °C under solvent-free conditions. This green protocol offers high yields, short reaction times, and catalyst reusability.

Source: Scientific Reports

DOI: 10.1038/s41598-025-25758-y

Authors: Zahra Jahanian, Davood Habibi, Arezo Monem, Elnaz Chegeni

Institution: Bu-Ali Sina University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: $2,690