Work

Palladium-Catalyzed One-Pot Synthesis of 3-Arylindoles Based on o -Iodoaniline with Aryl Hydrazones

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A tandem one-pot strategy for the efficient synthesis of indole derivatives has been developed via palladium-catalyzed coupling of ortho -iodoanilines with N -tosylhydrazones under basic conditions. The reaction proceeds through in situ formation of o -vinylaniline intermediates, followed by oxidative cyclization under palladium catalysis. The substrate scope study provided substituted 3-phenylindoles in moderate to good yields, demonstrating the method’s practicality for indole construction. Notably, no protection of the indole N–H is required, representing a key advantage.

Source: ACS Omega

DOI: 10.1021/acsomega.5c07730

Authors: Zhihao Du, Yue Chen, Tengyu Zhang, Dongsheng Chen, Yu Liu

Institution: Shanghai Institute of Pharmaceutical Industry

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funder: Science and Technology Commission of Shanghai Municipality