Charting the influence of deuterium sources in hydrogen isotope exchange using a cobalt(III) catalytic platform

Year: 2025

Type: article

Abstract: Directed hydrogen exchange is one of the main strategies for accessing isotopically labelled organic scaffolds, but the rationale for deuterium source selection has not been fully explored yet. Now the authors reveal the influence of the deuterium source in base-assisted site-selective C–H deuteration reactions across substrates in cobalt catalysis.

Source: Nature Catalysis

DOI: 10.1038/s41929-025-01447-x

Authors: Sergio Barranco, Inbal L. Eshel, Jiayu Zhang, Marco Di Matteo, Anat Milo, Mónica H. Pérez-Temprano

Institutions: Institut Català d'Investigació Química, Universitat Rovira i Virgili, Ben-Gurion University of the Negev

Language: English

Topic: Chemical Reactions and Isotopes

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $12,690

Funders: Ministerio de Ciencia, Innovación y Universidades, Centres de Recerca de Catalunya, Generalitat de Catalunya, Institut Català d'Investigació Química, China Scholarship Council, Agència de Gestió d'Ajuts Universitaris i de Recerca, Agencia Estatal de Investigación

OpenAlex ID: W4416673666