Effect of Matrix Metalloproteinase Inhibitors on the Bonding Durability of Nanocomposite Resin to Caries-affected Dentin: An In Vitro Study
Year: 2025
Type: article
Abstract: Aim: This in vitro study evaluated the microtensile bond strength (µTBS) of two nanohybrid resin composites to caries-affected dentin (CAD) after pretreatment with different hesperidin (HPN) concentrations, before and after thermocycling.Materials and methods: Eighty extracted human molars were assigned to two groups by composite type (Filtek Z250 XT, Grandio; n = 40 each) and subdivided into four pretreatment protocols (n = 10): control (no treatment), 0.5%, 1%, or 2% HPN.Half of the specimens in each subgroup were subjected to thermocycling.Microtensile bond strength was measured using a universal testing machine.Data were analyzed using two-way and three-way ANOVA followed by post hoc tests (α = 0.05).Results: Bond strength was significantly affected by HPN concentration and thermocycling.Non-aged Filtek and Grandio showed higher values (up to 39.90 ± 10.67 and 45.87 ± 13.37 MPa, respectively), while aging reduced strength in specific subgroups (Filtek no-treatment: p = 0.016; Grandio 0.5% HPN: p = 0.004; 2% HPN: p = 0.033).Overall, 0.5% HPN maintained better adhesive performance after aging, whereas higher concentrations showed diminished stability.Failure mode analysis supported these trends, with higher bond strength linked to cohesive/ mixed failures.Conclusion: Pretreatment with 0.5% HPN significantly improved bond strength and durability to CAD, while higher concentrations reduced performance, especially after thermocycling.Clinical significance: Applying 0.5% HPN as a dentin pretreatment may enhance the longevity of composite restorations in cases involving CAD.
Institutions: Sirte University, Mansoura University
Language: English
Subfield: Orthodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416673889