Photochemical aerobic synthesis of para-quinols in continuous flow mode
Year: 2025
Type: article
Abstract: The development of a simple and robust continuous flow method for the aerobic photo-oxidation of phenols is reported. This approach is attractive as it uses ambient air, which is the source of the singlet oxygen required in this transformation. Methylene blue is used in an aqueous solvent system in combination with either green or red LEDs. Although the latter LED option is advantageous because of its lower energy consumption, both approaches afford the desired para-quinol products in good yields after reduction of the para-peroxyquinol intermediates. The use of air at atmospheric pressure, along with low-energy LED sources and a benign solvent system, renders this flow method an attractive and easy to implement strategy for the generation of para-quinol products as valuable chemical building blocks.
Source: Australian Journal of Chemistry
DOI: 10.1071/ch25147
Authors: Kian Donnelly, Ishita Solanki, Tomás Vieira De Castro, Andrew L. Lawrence, Marcus Baumann
Institutions: University College Dublin, University of Edinburgh
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4416675094