Work

Transcription Factors in the Associative Gene Network of the Renin-angiotensin-aldosterone System in Humans

Year: 2025

Type: article

Abstract: Empirical and theoretical studies can be distinguished among the areas of investigation of the renin-angiotensin-aldosterone system (RAAS) and its relationship with the development of cardiovascular diseases. Theoretical work is based mainly on the bioinformatic analysis of key elements of RAAS (genes, proteins, metabolites), on calculations and predictions of protein interactions, and on mechanisms of RAAS gene expression regulation. An associative gene network based on big data analysis allows us to reveal relationships among the proteins, regulatory pathways, and biological processes acting in RAAS, as well as to identify new diagnostic markers, therapeutic targets, putative molecular mechanisms of the development of RAAS-associated diseases, drug interactions, and drug toxicity.

Source: Gene Expression

DOI: 10.14218/ge.2025.00050

Authors: O. Vishnevsky, K. Kuzminykh, I. Yatsyk, E. Kondratyuk, I. Chadaeva

Institutions: Novosibirsk State University, Institute of Cytology and Genetics, Institute of Clinical and Experimental Lymphology

Language: English

Topic: Renin-Angiotensin System Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4416675333