Work

High-grade undifferentiated prostatic sarcoma with heterologous differentiation: A rare case report and literature review

Year: 2025

Type: article

Abstract: Primary prostatic sarcomas are extremely rare, accounting for less than 0.1 % of prostatic malignancies. They arise from mesenchymal stromal cells and exhibit aggressive behavior. We report a 45-year-old man with progressive lower urinary tract symptoms, abdominal distension, and weight loss. Imaging revealed a large pelvic mass inseparable from the prostate. Exploratory laparotomy showed a >30 cm encapsulated tumor, completely excised with partial prostate. Histopathology confirmed a high-grade undifferentiated sarcoma with heterologous differentiation. At two-year follow-up, the patient remained disease-free. Complete surgical excision remains the cornerstone of management, while multimodal therapy may be considered for high-risk or recurrent cases.

Source: Urology Case Reports

DOI: 10.1016/j.eucr.2025.103289

Authors: Abenezer Bogale Abera, Lijalem Mekonnen Geremew, Hailemaryam Shiferaw, Shiferaw Gedefa Fentie, Yasin Worku

Institution: Wollo University

Language: English

Topic: Urologic and reproductive health conditions

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,160