Association Between Oral Lichen Planus and Non‐Oral Cancers: A Multicentre Case–Control SIPMO Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: This multicentre case-control study aimed to investigate the potential association between oral lichen planus (OLP) and extraoral cancers. The secondary objective included the identification of risk factors for this association. METHODS: The study was conducted between January 2023 and June 2024 and included 21 Italian Oral Medicine centres affiliated with the Italian Society of Oral Medicine (SIPMO). The study protocol was approved by the Ethics Committee of Università Cattolica del Sacro Cuore (Prot. ID 4073) and registered at clinicaltrials.gov (ID NCT06449248). RESULTS: In total, 1650 participants were enrolled (550 OLP and 1100 non-OLP patients) matched for age and sex. OLP patients showed a significantly higher prevalence of extra-oral cancers (19.8%) compared to controls (12.4%) with a 1.79 OR (1.34-2.39, p < 0.05). Moreover, erosive OLP (n = 32/120, 26.7%, p < 0.01) and plaque-like variants (n = 27/114, 23.7%, p < 0.04) seem to have a slightly increased risk of extra-oral cancer. CONCLUSIONS: Patients with OLP had a higher risk of developing extraoral cancer; moreover, erosive and plaque-like forms could be considered at higher risk. Potential pathogenic mechanisms involve an interplay between chronic inflammation, immune dysregulation and carcinogenesis. Therefore, the directionality of such association remains unclear, underscoring the need for prospective studies to clarify causality and temporal dynamics.
Source: Oral Diseases
DOI: 10.1111/odi.70152
Authors: Gioele Gioco, Anna Schiavelli, Alessandra Majorana, Elena Bardellini, Silvio Abati, Andrea Sardella, Francesco Spadari, Matteo Pellegrini, Dorina Lauritano, Raffaele Borgia, Monica Pentenero, Samuele Sutera, Paolo Giacomo Arduino, Alessio Gambino, Roberto Broccoletti, Matteo Biasotto, Giulia Ottaviani, Lorenzo Azzi, Alessandro D'Aiuto, Davide Bartolomeo Gissi, Andrea Gabusi, Andrea Santarelli, Marco Mascitti, Paolo Vescovi, Gloria Bortolotti, Maddalena Manfredi, Marco Meleti, Grazia Zino, Umberto Romeo, Gianluca Tenore, Gianfranco Favia, Luisa Limongelli, Massimo Petruzzi, Francesca Dimilito, Lorenzo Lo Muzio, Maria Eleonora Bizzoca, Giuseppina Campisi, Vera Panzarella, Stefania Leuci, Rosario Serpico, Alberta Lucchese, Giuseppe Colella, Giacomo Oteri, Antonia Marcianò, Gaetano Isola, Alessandro Polizzi, Amerigo Giudice, Elena Calabria, Umberto Mariani, Daniela Adamo, Federica Canfora, Filippo Graziani, Marco Nisi, Michele Giuliani, Luisa Ritrovato, Federica De Micheli, Cosimo Rupe, Francesco Scilla, Romeo Patini, Massimo Cordaro, Michele Davide Mignogna, Carlo Lajolo, SIPMO (Italian Society of Oral Pathology and Medicine)
Institutions: Università Cattolica del Sacro Cuore, Agostino Gemelli University Polyclinic, Istituti di Ricovero e Cura a Carattere Scientifico, University of Brescia, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Ferrara, University of Turin, University of Trieste, University of Insubria, Aziende Socio Sanitarie Territoriale dei Sette Laghi, University of Bologna, Marche Polytechnic University, University of Parma, Istituto Dermopatico dell'Immacolata, Sapienza University of Rome, University of Bari Aldo Moro, University of Foggia, Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo, University of Palermo, University of Naples Federico II, University of Campania "Luigi Vanvitelli", University of Messina, University of Catania, Magna Graecia University, Ospedale Papa Giovanni XXIII, Link Campus University, University of Pisa, Casa Sollievo della Sofferenza, Azienda Ospedaliera Ospedale Maggiore, Azienda Socio Sanitaria Territoriale di Cremona
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,990
Funders: Università degli Studi di Napoli Federico II, Università degli Studi di Milano, Università di Catania, Università degli Studi di Parma, Università degli Studi di Palermo, Università degli Studi dell'Insubria, Università Cattolica del Sacro Cuore, Università di Bologna, Università degli Studi di Torino, Università degli Studi di Ferrara, Università degli Studi di Brescia, Università di Pisa, Università degli Studi di Messina, Università degli Studi della Campania Luigi Vanvitelli, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
OpenAlex ID: W4416678313