Work

Transfer Hydrogenation of In Situ Generated Imines Enables Functionalized Isatin‐Hydrazones

Year: 2025

Type: article

Abstract: Herein, a transfer hydrogenation of in situ generated imine intermediates from readily available isatin-hydrazones with 1,4-benzoquinones or aldehydes by Brønsted acid catalysis was established. This efficient, mild ambient, operationally simple and safe approach afforded stereospecific functionalized isatin-3-arylhydrazones and isatin-3-alkylhydrazones in excellent yields (up to 95%).

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.202500666

Authors: Liu Song, Qiao Shi, Yi Cai, Juntao Ge, Dandan Zhu, Fei Yu

Institution: Chongqing University of Science and Technology

Language: English

Topic: Asymmetric Hydrogenation and Catalysis

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Chongqing University, Chongqing Science and Technology Commission, Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission, Chongqing University of Science and Technology

Awards: G2210806970, G4355723829, G6502608182