A comparative study of serum homocysteine levels among chronic obstructive pulmonary disease patients with and without acute exacerbation
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objectives: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Acute exacerbations of COPD significantly impact disease progression and patient outcomes. Serum homocysteine, a potential biomarker of systemic inflammation and oxidative stress, may play a role in COPD pathophysiology. This study aims to compare serum homocysteine levels between stable COPD patients and those experiencing acute exacerbations. Materials and Methods: Serum homocysteine levels were analyzed by enzymatic assay from the stable and acute exacerbation groups and correlated with the severity of COPD, along with erythrocyte sedimentation rate ( ESR ) and COPD assessment test (CAT) score results. Results: The serum homocysteine levels were significantly higher in the acute exacerbation group (18.2 + 7.6) compared to the stable COPD group (15.8 + 5.2). Higher serum homocysteine levels were seen in patients with higher CAT and ESR scores. Conclusion: Serum homocysteine is a valuable indicator associated with acute exacerbation of COPD. It also serves as a marker of disease severity in conjunction with ESR and CAT scores.
Authors: L. S. Adarsh, Prakruthi Mohan, B. S. Swathi, K. M. Srinath, M. Manthappa, S. Chandana
Institution: JSS Academy of Higher Education and Research
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416679348