Year: 2025
Type: article
Study design: Case Report
Abstract: We report the case of a 43-year-old man with cardiovascular risk factors such as hypertension, hypertriglyceridemia and non-alcoholic fatty liver disease. He was admitted with a complaint of exertional and persistent chest pain, accompanied by electrocardiographic changes suggestive of anterior ST-elevation myocardial infarction. Initial investigations, including coronary angiography and optical coherence tomography, revealed unobstructed coronary arteries and no evidence of plaque disruption. Transthoracic echocardiography demonstrated marked asymmetric septal hypertrophy with mild systolic anterior motion of the mitral valve and eccentric mitral regurgitation, in the absence of a resting or provoked left ventricular outflow tract gradient. Cardiac magnetic resonance imaging further confirmed a diagnosis of non-obstructive hypertrophic cardiomyopathy (HCM), with late gadolinium enhancement indicating patchy mid-septal and basal fibrosis. In view of these findings, dual antiplatelet therapy was discontinued, and the patient was managed with beta-blockers. He was discharged with plans for outpatient cardiology follow-up, risk stratification for sudden cardiac death, and genetic evaluation. This case highlights the potential for HCM to mimic acute coronary syndromes, particularly in a patient with cardiovascular risk factors, ischaemic ECG changes and ongoing chest pain. It underscores the diagnostic value of advanced imaging modalities in differentiating true myocardial infarction from phenocopies, thereby guiding appropriate and timely management.
Source: Cureus
DOI: 10.7759/cureus.97693
Institution: Blackpool Teaching Hospitals NHS Foundation Trust
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416679961