Normal cardiac lymphatics and their mimics
Year: 2025
Type: article
Abstract: This is the first study detailing normal lymphatic vessel distribution at various cardiac anatomical sites using a lymphatic reporter mouse model, multiple markers, and modern imaging modalities, providing a blueprint for future studies. We also performed integrated single-cell RNA sequencing (scRNA-Seq) analysis to define the cellular and transcriptional heterogeneity of cardiac lymphatic endothelial cells. Finally, our study underscores the nonspecific nature of lymphatic markers and emphasizes the necessity of using at least two markers to identify lymphatic vessels.
Authors: Sarah A. Ware, Lirong Zheng, Milad Almasian, Lorenzo Fernandes, Chitkale Hiremath, Jonathan A. Brewer, Zhi-Jing Wu, Claudia Muñoz Rodríguez, Shuyue Zhou, Denise K. Marciano, Yichen Ding, Michael T. Dellinger, Dan Tong
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: QuSeC-TAQS: Nanodiamond Quantum Sensing for Four-Dimensional Live-Cell Imaging, G2495305243, Targeting the "invisible" lymphatic system in heart failure with preserved ejection fraction, G2651375097, G2819641313, The Role of Nephronectin in Glomerular Development and Function, G386122907, Spinning Disk Confocal for UT Southwestern, The immune-cardiomyocyte crosstalk in cardiometabolic atrial fibrillation, G7313797249, G8577842003, Volumetric imaging and computation to characterize cardiac electromechanical coupling, Elucidating novel mechanisms in the pathogenesis of Alport syndrome, Protein acetylation-dependent fatty acid metabolic dysfunction in HFpEF, UT Southwestern Medical Center Simmons Comprehensive Cancer Center
OpenAlex ID: W4416679991