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A higher serum lipase cut-off improves the diagnosis of acute pancreatitis in patients with non-epigastric abdominal pain

Year: 2025

Type: article

Abstract: = 324) using imaging-proven AP as the reference. At >3-times ULN lipase cut-off, 15% (i.e., 129/863) patients had atypical pain. These were imaged more often (89% vs. 75%) but had lower AP diagnoses (34% vs. 62%) than others. A >7.5-times ULN cut-off for atypical pain reduced imaging by 40%, increased imaging-proven AP diagnosis (56-77% in both cohorts), increased specificity by 2-fold, while retaining sensitivity of ≥95%. Therefore, a >7.5-fold ULN improves AP diagnosis in atypical, i.e., non-epigastric pain. This may reduce costs, expedite AP management when cross-sectional imaging is not feasible, and improve outcomes.

Source: iScience

DOI: 10.1016/j.isci.2025.114074