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Author response: SMC5/6-mediated plasmid silencing is directed by SIMC1–SLF2 and antagonized by the SV40 large T antigen

Year: 2025

Type: peer-review

Abstract: Distinct SMC5/6 subcomplexes mediate the transcriptional silencing of circular extrachromosomal DNA (SIMC1–SLF2) and repair of chromosomal DNA lesions (SLF1–SLF2), thus enabling exploration of SMC5/6 functions in innate immunity and cancer.

Source: eLife

DOI: 10.7554/elife.106815.3.sa4

Authors: Martina Oravcová, Minghua Nie, Takanori Otomo, Michael N Boddy

Institutions: Scripps Research Institute, San Diego Biomedical Research Institute

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W4416690003

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