Tackling vaccine hyporesponsiveness through global collaboration, diverse population studies, and data integration
Year: 2025
Type: article
Abstract: Vaccines have improved global health substantially, preventing millions of deaths worldwide. However, striking variations in the immunogenicity and efficacy of some vaccines persist across populations. Notably, suboptimal responses to some vaccines, also known as vaccine hyporesponsiveness, have been observed in low-income and middle-income countries (LMICs) compared with high-income countries or in rural areas within LMICs compared with urban areas within LMICs. Environmental factors, host genetics, lifestyle, and nutrition contribute to immunological variations influencing vaccine responses, highlighting the need to identify key immune signatures that can be manipulated to overcome vaccine hyporesponsiveness. The integration of diverse datasets, accelerated by artificial intelligence, is essential to achieve this goal, which is currently hampered by the under-representation of data from LMICs. The HypoVax Global knowledge hub aims to address this gap by fostering international collaboration and compiling globally representative immunological data from population studies and vaccine trials. The hub offers a platform for high-dimensional data analyses, promotes equitable partnerships, and strives to ensure that all contributions lead to context-specific insights that can inform immunisation strategies to ultimately overcome vaccine hyporesponsiveness.
Source: The Lancet Microbe
Authors: Abena S Amoah, Abena S Amoah, Selidji T Agnandji, Michel Bengtson, Jennifer A Downs, Meral Esen, Jeevan Giddaluru, Simon P Jochems, Maria M M Kaisar, Julia Makinde, Mikhael D Manurung, Moustapha Mbow, Gemma Moncunill, Rajagopal Murugan, Jacqueline Mutai, Helder I Nakaya, Gyaviira Nkurunungi, Magnus Palmblad, Jeremia J Pyuza, Koen A Stam, Wouter A A de Steenhuijsen Piters, Bridgious Walusimbi, Maria Yazdanbakhsh, Ayola A Adegnika, Deeva Agravat, Syed K Ali, Abena S Amoah, Abena S Amoah, Yaw Bediako, Michel Bengtson, Sèyigbéna P D Berry, Jean-Luc Bodmer, Mariateresa Coppola, Claudia Daubenberger, Wouter A A de Steenhuijsen Piters, Claudia Demarta-Gatsi, Carlota Dobaño, Jennifer A Downs, Alison M Elliott, Meral Esen, Bart Everts, Rolf Fendel, Simon P Jochems, Said A Jongo, Maria M M Kaisar, Domtila Kimani, Ann W Kinyua, Cynthia Lungu, Adrian J F Luty, Jane K Maganga, Ahmed Mahfouz, Julia Makinde, Mikhael D Manurung, Moustapha Mbow, Matthew B B McCall, Annie X Mo, Gemma Moncunill, Benjamin G Mordmüller, Yoanne D Mouwenda, Rajagopal Murugan, Jacqueline Mutai, Irene N Nkumama, Gyaviira Nkurunungi, Nynke Ligtenberg, Ally I Olotu, Jeremia J Pyuza, Meta Roestenberg, Anna H E Roukens, Thomas Spangenberg, Koen A Stam, Lisa Stockdale, John S Tsang, Marloes M A R van Dorst, Bridgious Walusimbi, Maria Yazdanbakhsh, Gerhild Zauner
Institutions: Leiden University, Leiden University Medical Center, Centre de Recherche Médicales de Lambaréné, University Hospital Münster, University of Tübingen, Weill Cornell Medicine, Universitätsklinikum Tübingen, German Center for Infection Research, Universidade de São Paulo, Atma Jaya Catholic University of Indonesia, Imperial College London, Institute of Health Research, Epidemiological Surveillance and Training, Cheikh Anta Diop University, Instituto de Salud Carlos III, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red Enfermedades Infecciosas, Kenya Medical Research Institute, Vaccine and Gene Therapy Institute, KEMRI-Wellcome Trust Research Programme, Hospital Israelita Albert Einstein, London School of Hygiene & Tropical Medicine, MRC/UVRI & LSHTM Uganda Research Unit, Kilimanjaro Christian Medical Centre, KCMC University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $7,280
OpenAlex ID: W4416690837