Transcription factor CEBPA suppresses sepsis induced lung injury by activating SIRT4 transcription
Year: 2025
Type: article
Abstract: This study aimed to investigate the roles of the transcription factor CEBPA and the sirtuin family protein SIRT4 in sepsis-induced acute lung injury (ALI) through both cell-based experiments and animal models. Following LPS or sepsis treatment, both CEBPA and SIRT4 levels were significantly elevated, with a strong correlation observed between these proteins across various samples. Overexpression of CEBPA or SIRT4 mitigated LPS-induced damage, promoting cell survival, reducing apoptosis, and attenuating lung inflammation and injury. In mouse models of ALI, increased expression of CEBPA and SIRT4 substantially alleviated lung injury and inflammation, whereas silencing these genes exacerbated the condition. Further analysis revealed that CEBPA directly binds to the SIRT4 promoter, thereby enhancing SIRT4 protein expression, which in turn amplifies their protective effects. This study is the first to establish a functional link between CEBPA and SIRT4 in ALI, providing novel insights for the development of therapeutic strategies targeting inflammatory diseases.
Source: Scientific Reports
Authors: Zheqian Wu, Kunxiang Gou, Yong Wang, Lihua Dai
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W4416694252