Grey matter volume reduction and its association with brain-enriched blood biomarkers in out-of-hospital cardiac arrest survivors
Year: 2025
Type: article
Abstract: Elevated levels of blood-based biomarkers such as neurofilament light chain (NfL) and neuron-specific enolase (NSE) are associated with poor neurological outcome after out-of-hospital cardiac arrest (OHCA). This study investigates the relationship between regional grey matter volume reduction and levels of glial fibrillary acidic protein (GFAP), NfL, NSE, and total-tau (t-tau) protein. This substudy of the Xe-Hypotheca trial included 110 patients randomized to receive either inhaled xenon with target temperature management (TTM) at 33 °C for 24 h (n = 55) or TTM alone (n = 55). Voxel-based morphometry was used to assess grey matter volume changes in MRI scans acquired 36-52 h and 10 days after OHCA in 45 survivors. Blood biomarkers were measured upon intensive care unit arrival and at 24, 48 and 72 h post-OHCA. NfL levels positively correlated with grey matter volume reduction in the thalamus and cingulate cortex at 24 h post-OHCA. T-tau showed more extensive pattern of significant correlations, increasing in both magnitude and spatial extent from baseline to 48 h post-OHCA. No significant biomarker-volume associations were observed for GFAP or NSE, and no treatment group differences were detected. Elevated NfL and t-tau levels were associated with region-specific grey matter volume reduction within the first 10 days after OHCA. Among the four biomarkers studied, t-tau demonstrated the strongest and most widespread associations, suggesting its potential as a marker for early ischemic grey matter volume reduction after OHCA. ClinicalTrials.gov NCT00879892, 13/04/2009.
Source: Scientific Reports
Authors: Carita C. Hollmén, Victor Vorobyev, Riitta Parkkola, Jussi P. Posti, Jani Saunavaara, Ruut Laitio, Olli Arola, Marja Hynninen, Minna Bäcklund, Kaj Blennow, Henrik Zetterberg, Juha Martola, Emmi Ylikoski, Risto O. Roine, Marjaana Tiainen, Harry Scheinin, Mervyn Maze, Tero Vahlberg, Timo T. Laitio, Sami Virtanen, Juhani Airaksinen, Antti Saraste, Mikko Pietilä, Juha Grönlund, Outi Inkinen, Veli-Pekka Harjola, Kirsi Korpi, Marjut Varpula, Jussi Niiranen, Eija Nukarinen, Johanna Wennervirta, Klaus T. Olkkola, Päivi Silvasti, Heli Silvennoinen, Leena Valanne
Institutions: University of Turku, Turku University Hospital, University of Helsinki, Helsinki University Hospital, University of Science and Technology of China, Sahlgrenska University Hospital, Sorbonne Université, Pitié-Salpêtrière Hospital, Institut du Cerveau, University of Gothenburg, University of Wisconsin–Madison, National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology, University College London, Indian Institute of Science Bangalore, University of California, San Francisco
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W4416695213