Response to the Letter to the Editor: Recalibrating evidence: a cautionary note on the use of post hoc thresholds in IPD meta-analyses
Year: 2025
Type: letter
Abstract: We are grateful to the author of the letter for his interest in our recent paper, ‘Role of the calcium stimulation test in diagnosing medullary thyroid cancer: is it adequate to achieve a diagnosis in both sexes? An individual patient data meta-analysis’ in the European Thyroid Journal (2025), and for his comments on the methodological aspects of our IPD meta-analysis. We would like to clarify our methodological choices and address the concerns raised. Regarding the absence of PROSPERO registration, we recognize that registration would have improved transparency. We defined the analytic framework and objectives before conducting the analyses at the ‘NIKE’ (Neuroendocrine tumors Innovation Knowledge and Education) workshop held by Prof. Annamaria Colao, Prof. Antongiulio Faggiano, and Prof. Andrea M Isidori. The aim of the workshop was to boost the advancement of knowledge in various aspects of neuroendocrinology. However, we recognize the value of protocol registration to limit potential bias. This limitation was acknowledged in our paper, and we agree that future research should adopt protocol registration as a standard practice.
Source: European Thyroid Journal
DOI: 10.1530/etj-25-0323
Authors: Franz Sesti, Tiziana Feola, Pasquale Dolce, Valentina Guarnotta, Alessandro Veresani, Elia Guadagno, Filomena Bottiglieri, Maria Grazia Tarsitano, Mauro Salducci, Andrea M Isidori, Annamaria Colao, Antongiulio Faggiano, Elisa Giannetta, on behalf of NIKE group, Annamaria Colao, Antongiulio Faggiano, Manuela Albertelli, Barbara Altieri, Luigi Barrea, Nazarena Betella, Severo Campione, Federica Campolo, Giuseppe Cannavale, Roberta Centello, Alessia Cozzolino, Paola Crivelli, Federica de Cicco, Andrea Dicitore, Sara Di Meglio, Sergio Di Molfetta, Valentina Di Vito, Andrea Dotto, Giuseppe Fanciulli, Francesco Ferraù, Emanuele Filice, Marco Gallo, Federica Grillo, Erika Grossrubatcher, Anna La Salvia, Elisabetta Lavezzi, Fabio Lo Calzo, Pasqualino Malandrino, Chiara Martini, Andrea Lania, Rossella Mazzilli, Erika Messina, Nevena Mikovic, Roberto Minotta, Roberta Modica, Giovanna Muscogiuri, Soraya Olana, Genoveffa Pizza, Alice Plebani, Gabriella Pugliese, Giulia Puliani, Alberto Ragni, Manila Rubino, Rosaria M Ruggeri, Giovanni Vitale, Virginia Zamponi, Isabella Zanata, Maria Chiara Zatelli
Language: English
Subfield: Statistics, Probability and Uncertainty
Field: Decision Sciences
Domain: Social Sciences
Open Access status: diamond
OpenAlex ID: W4416703466
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